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Amphetamine is understood to inhibit monoamine oxidase, whereas the flexibility of amphetamine and its metabolites to inhibit various P450 isozymes along with other enzymes has not been sufficiently elucidated. In vitro experiments with human microsomes point out minor inhibition of CYP2D6 by amphetamine and minor inhibition of CYP1A2, 2D6, and 3A4

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